40478_2020_948_MOESM2_ESM.tif (9.52 MB)
Additional file 2 of Humanized tau antibodies promote tau uptake by human microglia without any increase of inflammation
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posted on 2020-05-30, 03:45 authored by Monika Zilkova, Anna Nolle, Branislav Kovacech, Eva Kontsekova, Petronela Weisova, Peter Filipcik, Rostislav Skrabana, Michal Prcina, Tomas Hromadka, Ondrej Cehlar, Gabriela Paulikova Rolkova, Denisa Maderova, Michal Novak, Norbert Zilka, Jeroen J. M. HoozemansAdditional file 2. Supplementary Fig. S. 2 AX004-mediated tau uptake is not affected by diagnosis of donors from which primary human microglia cultures were derived. Human microglia cultures from 4 control cases without neurodegeneration, 5 tauopathy patients (AD, PSP, Pick’s disease) and 4 patients with other neurodegeneration (MS, MSA, PD) were compared for tau uptake. Diagnosis of patients did not have an effect on antibody-mediated tau uptake by microglia. The values were normalized to the corresponding isotype control values.
