Additional file 2: of Cytolytic activity correlates with the mutational burden and deregulated expression of immune checkpoints in colorectal cancer

Figure S2. Enrichment of selected immune-related gene sets in CYT-high colon (COAD) and rectum (READ) adenocarcinomas. A. Cytolytic-high tumors show increased enrichment of gene sets from activated, cytolytic CD8+ T-cell populations and PD1high CD8 T-cells [38, 39]. B. Gene set variation analysis (GSVA) of known immune-related gene sets shows statistically significant increase in CYT-high colon and rectal tumors. (JPG 2337 kb)