Additional file 2: of Classification, substrate specificity and structural features of D-2-hydroxyacid dehydrogenases: 2HADH knowledgebase

Figure S1. Maximum-likelihood evolutionary tree of the 2HADH family. The branch labels correspond to UniProt accessions of proteins with studied substrate specificities (orange dots), known crystal structures (green dots), or both (red dots). The scale bar represents the number of estimated changes per position. A crystal structure of GHRC from Desulfovibrio vulgaris (PDB ID: 5tx7) was solved after the analysis was performed, and is not shown in the figure. (PDF 56 kb)