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Additional file 2: of Chitinase-3-like 1 protein (CHI3L1) locus influences cerebrospinal fluid levels of YKL-40

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posted on 2016-11-10, 05:00 authored by Yuetiva Deming, Kathleen Black, David Carrell, Yefei Cai, Jorge Del-Aguila, Maria Fernandez, John Budde, ShengMei Ma, Benjamin Saef, Bill Howells, Sarah Bertelsen, Kuan-lin Huang, Courtney Sutphen, Rawan Tarawneh, Anne Fagan, David Holtzman, John Morris, Alison Goate, Joseph Dougherty, Carlos Cruchaga
Supplementary Methods and Results. Methods and results for the gene ontology over-representation analyses of top SNPs from the single variant analysis of CSF YKL-40 levels. 70 genes mapped to the top SNPs (p < 1 × 10-4) were significantly enriched in human brain and pituitary tissue at all levels of specificity. Figure illustrates the different human tissues with expression data available with Benjamini-Hochberg corrected p < 0.10 in the enrichment analysis and the Table shows the results for all tissues with uncorrected p < 0.05 in at least one specificity index. The specificity index represents how specific a set of genes are to a particular tissue. (DOCX 163 kb)

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National Institutes of Health

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