Additional file 2: of Blockade of PDGFRβ circumvents resistance to MEK-JAK inhibition via intratumoral CD8+ T-cells infiltration in triple-negative breast cancer

Figure S1: (A) Dysregulation score was calculated according to Pathifier [32] for MAPK and JAK/STAT signaling in breast cancer using TCGA dataset. (B, C) A combined panel of selected breast cancer and near-normal cell lines was reverse-transfected with 10 nM pooled JAK1, JAK2, STAT3 or KRAS siRNAs and cell viability determined after 6 days. Cell viability relative to its own respective control transfected with scramble siRNA was calculated, n = 2–3 (*p < 0.05, p < 0.01). Individual cell lines are shown in panel C. (JPG 2069 kb)