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Additional file 2: of Bioenergetic bypass using cell-permeable succinate, but not methylene blue, attenuates metformin-induced lactate production

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posted on 2018-08-01, 05:00 authored by Sarah Piel, Johannes Ehinger, Imen Chamkha, Eleonor Frostner, Fredrik Sjövall, Eskil Elmér, Magnus Hansson
Effect of methylene blue (1 μM), the cell-permeable succinate prodrugs NV189 and NV241 (250 μM), and succinate (250 μM) on lactate production in metformin-induced mitochondrial dysfunction in human platelets. (PDF 238 kb)

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Swedish government project and salary funding for clinically oriented medical research (ALF-grants)

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    Intensive Care Medicine Experimental

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    Cell-permeable succinateHuman plateletsLactic acidosisMetforminMethylene blueMitochondrial respirationMitochondrial toxicity

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    CC BY 4.0

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