Additional file 2: of Augmented antitumor activity by olaparib plus AZD1775 in gastric cancer through disrupting DNA damage repair pathways and DNA damage checkpoint

Figure S2. Effects of AZD1775 plus olaparib on SSB accumulations, PARP trapping and prolonged mitosis in GC cells. (a-c) after drug treatment as indicated, proteins extracted from whole cell lysates or chromatin were probed with indicated antibodies. Trapped/total PARP1 indicated the ratios of PARP1 levels in chromatin to PARP1 levels in whole cell lysates which were then normalized to controls. Noco, Nocodazole. (TIF 647 kb)