Additional file 2: of A novel BMI-1 inhibitor QW24 for the treatment of stem-like colorectal cancer

Figure S2. QW24 inhibits colorectal cancer cells proliferation more significantly than PTC-209. A, HCT116, HT29 and HCT8 cells were treated with indicated concentrations of PTC-209 or QW24 for 7 days, and the cell colonies were counted. Data are presented as mean ± s.d. (n = 3); *, P < 0.05; **, P < 0.01; ***, P < 0.001. B, HT29, HCT8 and CT26 cells were seeded in 96-well plates (3000 cells/well) and treated with 0, 0.5, 1, 2, 4 μM of QW24 or PTC-209 after cells were attached. After 72 h incubation, cell growth was determined by SRB assay. Data are presented as mean ± s.d. (n = 5); *, P < 0.05; **, P < 0.01; ***, P < 0.001. (DOCX 210 kb)