Additional file 2: Figure S2. of Differential ability of MSCs isolated from placenta and cord as feeders for supporting ex vivo expansion of umbilical cord blood derived CD34+ cells

Cells expanded on P-MSCs gave rise to persistent engraftment in NOD/SCID mice. a Superior multi-lineage engraftment as denoted by donor-derived CD34 (stem cells), CD33 (myeloid cells), CD56 (NK cells), CD19 (B-cells), and CD3 (T-cells) after 12 weeks was detected in bone marrow of animals receiving cells from P-MSCs co-cultures as opposed to C-MSCs co-cultures (n = 10). b Mice infused with cells expanded on P-MSCs showed significantly higher numbers of donor-derived progenitors (CFU) after 12 weeks. c Multi-lineage engraftment in secondary recipient also showed superiority of the cells expanded on P-MSCs. (n = 9). d Secondary recipient similarly displayed a significantly higher number of human CFC in the mice receiving cells from primary recipient infused with cells from P-MSCs:CD34+ co-cultures. (n = 9). Data are represented as mean ± standard deviation from ten different mice. *p ≤ 0.05, **p ≤ 0.01, and ***p ≤ 0.001. (TIFF 2354 kb)