Additional file 2: Figure S1. of Antagonizing miR-455-3p inhibits chemoresistance and aggressiveness in esophageal squamous cell carcinoma

miR-455-3p enhances ESCC chemoresistance and promotes ESCC tumorgencity. (A) GSEA of TCGA datasets indicating that miR-455-3p expression was significantly correlated with chemoresistance gene signatures. (B) The apoptotic ratio of the indicated cells treated with CDDP (20 μM) or DOC (1.5 nM) for 24 h. (C) Images (left) and weight (upper right) of xenografts and apoptotic ratio (lower right) of the indicated tumors. (D) GSEA analysis indicating miR-455-3p expression was significantly associated with stem cell-like traits. (E) Representative images (left) and quantification (right) of tumorspheres formed by the indicated cells. (F) Flow cytometry analysis of the percentages of the CD90+/CD271+ subpopulations (left) and SP cells (right) of the indicated cells. Each bar represents the mean ± SD of three independent experiments. * P < 0.05. (TIFF 1054 kb)