12943_2015_456_MOESM2_ESM.eps (2.98 MB)
Additional file 2: Figure S1. of Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer
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posted on 2015-10-24, 05:00 authored by Jessica Bauer, Ozkan Ozden, Naomi Akagi, Timothy Carroll, Daniel Principe, Jonas Staudacher, Martina Spehlmann, Lars Eckmann, Paul Grippo, Barbara JungACVR2 interacts with p85 after activin treatment. FET cells were used for co-immunoprecipitation with ACVR2, TGFBR1 or TGFBR2 and Western blotted with p85. There is an induction of ACVR2/p85 association following activin treatment, however, the increase in ACVR1/p85 association was more pronounced. Neither TGFBR1 nor TGFBR2 directly associated with p85 following ligand stimulation. (EPS 3051 kb)
