13148_2020_816_MOESM1_ESM.pdf (5.98 MB)
Additional file 1 of Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent cognitive impairment in C9orf72 BAC transgenic mice
journal contribution
posted on 2020-02-19, 05:16 authored by Nur Jury, Sebastian Abarzua, Ivan Diaz, Miguel Guerra, Estibaliz Ampuero, Paula Cubillos, Pablo Martinez, Andrea Herrera-Soto, Cristian Arredondo, Fabiola Rojas, Marcia Manterola, Adriana Rojas, Martín Montecino, Lorena Varela-Nallar, Brigitte ZundertAdditional file 1: Figure S1. ACM derived from C9BAC astrocytes significantly reduces motoneuron survival. Figure S2. Loss of H3K9me3 staining in N2A cells treated with chaetocin. Figure S3. H3K9me3 staining overview in primary astrocytes cultured reveals global reduction of H3K9me3 fluorescence intensity. Figure S4. H3K9me3 staining in striatal neurons from C9BAC and control mice. Figure S5. H3K9me3 staining in hepatocytes and Sertoli cells from C9BAC and control mice.
