Additional file 1: of Variability in metabolic parameters and risk of dementia: a nationwide population-based study

Table S1. Characteristics of subjects according to incident dementia. Tables S2–S4. HR (95% CI) of all-cause dementia, Alzheimer’s disease, and vascular dementia by quartiles of metabolic parameter variability measured as CV (model 1), as SD, and as VIM. Tables S5–S11. HR (95% CI) of all-cause dementia, Alzheimer’s disease, and vascular dementia by number of parameters with high variability with covariates selected by backward stepwise elimination, measured as SD, measured as VIM, by sensitivity analysis excluding subjects with the occurrence of end points within 3 years of follow-up, by sensitivity analysis excluding diseases known as a risk factor of dementia, by further adjusting for diseases known as a risk factor of dementia, and with high variability defined as > 1 SD. Table S12. HR (95% CI) of all-cause dementia, Alzheimer’s disease, and vascular dementia by weighted variability score. Tables S13–S14. HR (95% CI) of all-cause dementia, Alzheimer’s disease, and vascular dementia by number of parameters with high variability measured as CV by sensitivity analysis (censoring cases with incident diabetes mellitus, hypertension, or dyslipidemia during the follow-up period) and in total population or subjects with metabolic disease at baseline. Figures S1–S2. Cumulative incidence of all-cause dementia, Alzheimer’s disease, and vascular dementia according to number of metabolic parameters with high variability defined as highest quartile of SD and of VIM. Figures S3–S4. Incidence rate, HR (95% CI) of all-cause dementia, Alzheimer’s disease, and vascular dementia according to variability score as SD and as VIM. Figures S5–S6. HR (95% CI) of all-cause dementia (A), Alzheimer’s disease (B), and vascular dementia (C) by number of metabolic parameters with high variability defined as highest quartile of SD and VIM (subgroup analyses according to age, sex, and presence or absence of obesity) (DOC 1137 kb)