Additional file 1: of Three miRNAs cooperate with host genes involved in human cardiovascular disease

2019-08-30T04:38:28Z (GMT) by Yan Zhu Jingjing Xie Hong Sun
Figure S1. Schematic representation of the study design. Figure S2. Genomic location and sequence conservation of the human miR-3182 gene. A, Evolutionary conservation across 30 mammals is measured by PhastCons and PhyloP score. B, Pairwise alignment between the human miR-3182 gene and its gorila ortholog. Figure S3. Genomic location and sequence conservation of the human miR-6863 gene. Evolutionary conservation across 30 mammals is measured by PhastCons and PhyloP score. Figure S4. Genomic location and sequence conservation of the human miR-5582 gene. Evolutionary conservation across 30 mammals is measured by PhastCons and PhyloP score. Table S1. Targets of miR-3182 used for GSEA analysis. The NetWAS scores, which describe the probability of interaction between the host gene CDH13 and the predicted targets of miR-3182, are replaced by their fractional ranks. Validated targets are highlighted with a star. Table S2. Targets of miR-6863 used for GSEA analysis. The NetWAS scores, which describe the probability of interaction between the host gene SLC12A3 and the predicted targets of miR-5582, are replaced by their fractional ranks. Validated targets are highlighted with a star. Table S3. Targets of miR-5582 used for GSEA analysis. The NetWAS scores, which describe the probability of interaction between the host gene CKAP5 and the predicted targets gene of miR-5582, are replaced by their fractional ranks. Validated targets are highlighted with a star. (DOC 6113 kb)