Additional file 1: of Synthesis of a benzoxazinthione derivative of tanaproget and pharmacological evaluation for PET imaging of PR expression

Reaction Scheme for synthesis of precursor 7; 1H, 13C, 19F NMR data and HPLC purity analysis for compounds 1, 2, 3, 4, 5, 6 and 7; radio-HPLC analysis of [18F]1 and [18F]2; Molar activity calibration curve; Log D calculation raw data; plotted data for T47D assay; In vitro cross reactivity assay data; TACs for in vivo evaulation of [18F]2; ex vivo biodistribution data for [18F]2; HPLC metabolite analysis for [18/19F]2; MS metabolite analysis for [19F]2. (DOCX 3180 kb)