Additional file 1: of Suppression of NLRP3 inflammasome improves alveolar bone defect healing in diabetic rats

Figure S1. Regulation of alveolar bone defect healing by shRNA targeting NLRP3 under the diabetic condition. a Increased expression of NLRP3 leads to the enhanced expression of ASC and caspase-1, subsequently resulting in the augmented release of proinflammatory cytokine IL-1β and decreased production of osteogenic markers RUNX2 and OCN under the diabetic condition. b shRNA targeting NLRP3 reduces the mRNA level of NLRP3 and inhibits the process shown in Figure S1a. (TIF 1473 kb)