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Additional file 1: of Serp-2, a virus-derived apoptosis and inflammasome inhibitor, attenuates liver ischemia-reperfusion injury in mice
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posted on 2019-05-29, 05:00 authored by Jordan Yaron, Hao Chen, Sriram Ambadapadi, Liqiang Zhang, Amanda Tafoya, Barbara Munk, Dara Wakefield, Jorge Fuentes, Bruno Marques, Krishna Harripersaud, Mee Bartee, Jennifer Davids, Donghang Zheng, Kenneth Rand, Lisa Dixon, Richard Moyer, William Clapp, Alexandra LucasFigure S1. Serp-2 mediated protection against LIRI at 24 hours does not prevent cleavage of caspases 1, 3 and 8. (a) Immunoblot analysis of 2 mice each from sham surgery or from 90 minutes liver ischemia-reperfusion injury at 24 hours follow-up probed for antibodies against cleaved caspase-3 (p19), full length/cleaved caspase-8 (p45/p18) and full length/cleaved caspase-1 (p45/p20) with actin as a loading control. (b) Densitometry of cleaved bands for caspases-1, -3 and -8 normalized to actin. Statistics performed by 2-Way ANOVA with Fisherâs LSD. (TIF 361 kb)
