13045_2018_693_MOESM1_ESM.docx (585.84 kB)
Additional file 1: of Safety and clinical activity with an anti-PD-1 antibody JS001 in advanced melanoma or urologic cancer patients
journal contribution
posted on 2019-01-14, 05:00 authored by Bixia Tang, Xieqiao Yan, Xinan Sheng, Lu Si, Chuanliang Cui, Yan Kong, Lili Mao, Bin Lian, Xue Bai, Xuan Wang, Siming Li, Li Zhou, Jiayi Yu, Jie Dai, Kai Wang, Jinwei Hu, Lihou Dong, Haifeng Song, Hai Wu, Hui Feng, Sheng Yao, Zhihong Chi, Jun GuoFigure S1. Phase I study schema of JS001 in advanced melanoma, renal cell carcinoma, and urothelial carcinoma. Figure S2. The PK profiles of JS001 in humans. Figure S3. The percentage of activated CD8+ T cell population during JS001 treatment. Figure S4. Correlation of tumor mutational burden (TMB) with clinical efficacy. Table S1. Treatment-related serious adverse events (SAE). Table S2. Grade 3 and above treatment-related adverse events (TRAE) in each cohort. Table S3. PD-1 receptor occupancy (RO) by JS001 in three dose cohorts. Table S4. Subgroup analysis of correlation with clinical efficacy. Table S5. Tumor mutational burden measurement and correlation with clinical response. (DOCX 575Â kb)
