Additional file 1 of Re-formulating Gehan’s design as a flexible two-stage single-arm trial

Survey of studies utilising Gehan’s design and Design comparison based on Lorenzen et al. (2008). Details of how the survey to evaluate the number of studies that have utilised Gehan’s design was conducted are provided. In addition, an additional comparison of the performance of Gehan’s and Simon’s designs is given, based on the trial reported in Lorenzen et al. (2008) [17]. (PDF 181 kb)