Additional file 1: of Phloretin attenuates STAT-3 activity and overcomes sorafenib resistance targeting SHP-1–mediated inhibition of STAT3 and Akt/VEGFR2 pathway in hepatocellular carcinoma

Figure S1. Colorimetric assay of caspase-3, -8 and -9 activity in HepG2 and Sk-Hep1. (A) Cells were treated with PH or Sor or both at indicated doses for 48 h and caspase-3, -8 and -9 activities were measured by colorimetric kits from Abcam, Cambridge, MA, USA). Experiments were conducted in triplicate and mean values ± SD (bars) are shown. *p < 0.05, and **p < 0.01 versus control. (DOCX 161 kb)