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Additional file 1: of Microglia processes associate with diffusely injured axons following mild traumatic brain injury in the micro pig

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posted on 2015-10-06, 05:00 authored by Audrey Lafrenaye, Masaki Todani, Susan Walker, John Povlishock
Processes of ramified microglia primarily pass over normal myelinated fibers in the sham thalamus. Movie representing 3D reconstructions of confocal z-stacks of thalamic sites from sham-injured animals, in which Dapi-labeled nuclei are in blue, MBP+ myelinated axons are in red, and Iba-1+ microglia are in white. Purple circles highlight contacts between microglial processes and normal myelinated fibers. Notice that while only a few microglial processes come in direct apposition with normal myelinated fibers, the majority of microglial processes that do contact myelinated fibers do not terminate at the axon; rather pass over the myelinated fiber. Scale bar: 10 Οm. (MP4 16442 kb)

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U.S. Army (US)

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