Additional file 1 of Integrative and quantitive evaluation of the efficacy of his bundle related pacing in comparison with conventional right ventricular pacing: a meta-analysis

Figure S1. QRS duration of HBRP compared to the one at baseline: this figure showed the difference between post long-term HBRP QRS duration and intrinsic QRS duration at baseline (WMD = weight mean difference, and CI = confidence interval). Figure S2. Fluoroscopic time and lead impedence of HBRP compared to RVAP’s: this figure showed fluoroscopic time and lead impedence of HBRP compared to RVAP’s. A showed higher dose of radiation in HBRP during the procedure; B showed lower lead impedence in HBRP measured during the procedure. Figure S3. Pacing threshold and pacing R wave amplitude of HBRP compared to ones of RVAP: this figure showed pacing threshold and pacing R wave amplitude of HBRP compared to ones of RVP. A showed pacing threshold of HBRP different from the one of RVP during procedure; B showed difference of amplitude of R wave between 2 different pacing patterns. Figure S4: this figure presented horizontal funnel plots for test of publication bias: A. LVEF; B. LVEDV; C. LVESV; D. inter-ventricular asynchrony; E. NYHA class; F. mitral regurgitation; G. myocardial performance index (Tei index); H. 6MWT; I. PASP; J. QRS duration (HBRP versus baseline); K. QRS duration (HBRP versus RVP); L. fluoroscopy exposure time; M. lead impedence; N. pacing threshold; O. amplitude of R wave. Table S1. Sensitivity analysis of different group of studies for each parameter: this table showed sensitivity analyses by the way of exclusion of 1 study at a time to determine the stability of the overall treatment effects (LVEF = left ventricular ejection fraction, LVEDV = left ventricular end diastolic volume, LVESV = left ventricular end systolic volume, NYHA = New York Heart Association, MPI = myocardial performance index, 6MWT = 6 min walk test, PASP = pulmonary artery systolic pressure, Pth = pacing threshold, and RWA = R wave amplitude) (DOCX 355 kb)