Additional file 1: of In vivo genome and base editing of a human PCSK9 knock-in hypercholesterolemic mouse model

Carreras, Alba; Pane, Luna; Nitsch, Roberto; Madeyski-Bengtson, Katja; Porritt, Michelle; Akcakaya, Pinar; Taheri-Ghahfarokhi, Amir; Ericson, Elke; Bjursell, Mikael; Perez-Alcazar, Marta; Seeliger, Frank; Althage, Magnus; Knöll, Ralph; Hicks, Ryan; Mayr, Lorenz; Perkins, Rosie; Lindén, Daniel; Borén, Jan; Bohlooly-Y, Mohammad; Maresca, Marcello

doi:10.6084/m9.figshare.7591937.v1

12915_2018_624_MOESM1_ESM.pdf (3.7 MB)

Additional file 1: of In vivo genome and base editing of a human PCSK9 knock-in hypercholesterolemic mouse model

journal contribution

posted on 2019-01-15, 05:00 authored by Alba Carreras, Luna Pane, Roberto Nitsch, Katja Madeyski-Bengtson, Michelle Porritt, Pinar Akcakaya, Amir Taheri-Ghahfarokhi, Elke Ericson, Mikael Bjursell, Marta Perez-Alcazar, Frank Seeliger, Magnus Althage, Ralph Knöll, Ryan Hicks, Lorenz Mayr, Rosie Perkins, Daniel Lindén, Jan Borén, Mohammad Bohlooly-Y, Marcello Maresca

Figure S1. Liver-specific expression of human PCSK9 in the hPCSK9-KI mouse model. (a) Representative micrographs of liver tissues from a WT (left) and a hPCSK9-KI mouse (right) showing expression of human PCSK9 (hPCSK9, brown) only in the hPCSK9-KI mouse liver. (b) Representative micrographs of tissues from a hPCSK9-KI mouse showing no hPCSK9 expression in pancreatic islets, skeletal muscle, kidney, white adipose tissue (WAT), brown adipose tissue (BAT), and spleen. Tissues were incubated with antibodies against hPCSK9. Scale bars, 200 μm. (PDF 3790 kb)