Additional file 1: of Identification of novel biomarker as citrullinated inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in sera with experimental and rheumatoid arthritis

Figure S1. DBA/1 mice were immunized with pGPI. (a) The clinical score (mean ± SEM) of pGIA (n = 11). (b) Sera were obtained once per week between days 0 and 28 from pGIA and control mice. The titers of anti-CCP antibodies were analyzed by ELISA (n = 12–18). Each symbol represents a single mouse, and the horizontal and vertical bars represent the mean and SEM values, respectively. *p < 0.05, **p < 0.01. (TIFF 120 kb)