12974_2018_1126_MOESM1_ESM.tif (1.32 MB)
Additional file 1: of HIV-1 Tat-induced diarrhea is improved by the PPARalpha agonist, palmitoylethanolamide, by suppressing the activation of enteric glia
figure
posted on 2018-03-24, 05:00 authored by Giovanni Sarnelli, Luisa Seguella, Marcella Pesce, Jie Lu, Stefano Gigli, Eugenia Bruzzese, Roberta Lattanzi, Alessandra D’Alessandro, Rosario Cuomo, Luca Steardo, Giuseppe EspositoPEA failed to inhibit bisacodyl-induced diarrhea in rats. Bisacodyl (20 mg/kg) caused a significant increase of (a) daily defecation frequency, (b) average daily number of wet spots, and (c) fluid accumulation within 7 days from diarrhea induction, vs. vehicle group. PEA (2–10–50 mg/kg) resulted ineffective to exert any anti-diarrheal activity. The results are expressed as mean ± SEM of n = 5 experiments. ***p < 0.001 vs. vehicle group. (TIFF 1347 kb)
