Additional file 1: of Gene connectivity and enzyme evolution in the human metabolic network

Figure S1. Reaction graph generated from the human metabolic network reconstruction Recon3D. Figure S2. Distribution of the selection estimates calculated for genes with 1:1 orthologs in the 6 species (Human, Chimpanzee, Gorilla, Orangutan, Mouse, and Rat) in the global metabolic network. Figure S3. Correlation matrices between variables. Figure S4. Relationship between selection estimates and connectivity (degree, in-degree and out-degree) in the global metabolic network. Figure S5. Relationship between selection estimates and position. Figure S6. Number of genes under positive selection in each functional pathway of the global metabolic network. Figure S7. Distribution of the number of enzymatic reactions carried by a given gene. (DOCX 1804 kb)