Additional file 1: of Efficacy of a topical gabapentin gel in a cisplatin paradigm of chemotherapy-induced peripheral neuropathy

Table S1. Effect of per se treated topical gabapentin 10% gel (GBP-10%), topical control gel (CG) and systemic gabapentin at 75 mg/kg (GBP-75, i.p.) during the expression of cisplatin-induced static allodynia [diminished von Frey filament threshold pressure (paw withdrawal threshold; PWT in g)] in hind paws after weekly intraperitoneal injection of cisplatin at 3.0 mg/kg (Cis-3) for four consecutive weeks in rats. Table S2. Effect of per se treated topical gabapentin 10% gel (GBP-10%), topical control gel (CG) and systemic gabapentin at 75 mg/kg (GBP-75, i.p.) during the expression of cisplatin-induced heat hypoalgesia [increased nociceptive response latency to heat stimulus in the hot-plate paradigm (paw withdrawal latency; PWL in s)] in bilateral hind paws after weekly intraperitoneal injection of cisplatin at 3.0 mg/kg (Cis-3) for four consecutive weeks in rats. Table S3. Effect of per se treated topical gabapentin 10% gel (GBP-10%), topical control gel (CG) and systemic gabapentin at 75 mg/kg (GBP-75, i.p.) on rotarod performance during neuropathic nociception induced after weekly intraperitoneal injection of cisplatin (Cis) at 3.0 mg/kg (Cis-3) for four consecutive weeks in rats. Table S4. Effect of per se treated topical gabapentin 10% gel (GBP-10%), topical control gel (CG) and systemic gabapentin at 75 mg/kg (GBP-75, i.p.) on footprint pattern analysis during neuropathic nociception induced after weekly intraperitoneal injection of cisplatin (Cis) at 3.0 mg/kg (Cis-3) for four consecutive weeks in rats. The measured parameter was expressed as the overlap distance between the forepaw and hind paw placements, 1 h post treatment. (DOCX 20 kb)