Additional file 1: of Counteracting roles of MHCI and CD8+ T cells in the peripheral and central nervous system of ALS SOD1G93A mice

Figure S1. MHCI depletion affect the number of CD3+ / CD4+ T cells but not their extent of infiltration in the spinal cord during the disease progression. Figure S2. MHCI depletion reduces the impairment of the cervical motor neurons in mSOD1 mice. Figure S3. MHCI depletion lowered the CD68 mRNA levels in the spinal cord of mSOD1 mice. Figure S4. MHCI depletion did not affect the extent of astrocytosis in the cervical and the lumbar spinal cord of G93A+/+ mice. Figure S5. MHCI expression is lower in the cervical than in the lumbar spinal cord of G93A+/+ mice. Figure S6. MHCI depletion accelerates denervation of hindlimb muscles in mSOD1mice. Figure S7. MHCI depletion inhibits the proliferation of the terminal Schwann cells and the size of AChR clusters in SOD1 mutant mice. Figure S8. MHCI depletion accelerates the atrophy of hindlimbs muscles in SOD1 mutant mice. Figure S9. MHCI depletion preserves the diaphragm innervation in SOD1 mutant mice. Figure S10. GFAP and phospho-ERK expression are reduced in the sciatic nerve of NTG-/- mice. Figure S11. Myelin basic protein isoforms are markedly dwonregulated in the sciatic nerve of G93A-/- mice at 140 d. Figure S12. Regional and temporal differences defines the disease progression of mSOD1 mice. (DOCX 21 kb)