Additional file 1: of Chromatin accessibility plays a key role in selective targeting of Hox proteins

Figure S1. The association between Hox specificity and binding site affinity, binding region numbers and chromatin accessibility profiles; Figure S2. Hox, Hox+Hth, Hth and Exd binding in open and closed chromatin; Figure S3. Motif analysis showing individual motifs; Figure S4. De-novo motif analysis of Exd/Hth cofactor enhanced binding regions; Figure S5. Comparing the effects of Exd/Hth and Gcm: Chromatin accessibility in Hox + Exd/Hth compared to Hox + Gcm; Figure S6. Hox occupancy is more strongly associated with binding region chromatin accessibility than with binding affinity; Figure S7. The presence of Exd/Hth leads to both enhanced and reduced Abd-B binding; Figure S8. Comparison of Ubx and Dfd binding in presence of Gcm for regions in basal Kc167 closed chromatin; Table S1. ChIP-seq read overview; Table S2. ChIP-Seq binding region numbers; Table S3. Stable cell lines ATAC-seq read overview; Table S4. Cofactor-enhanced binding analysis of transient data in Hox group peak regions; Table S5. Increased chromatin accessibility analysis. (PDF 5942 kb)