Diagram of the force-directed layout constraint algorithm. The diagram represents the basic concept about how nodes’ positions are redefined by our constraining algorithm during the force-direct layout iterations. It shows how a node is moved from cytosol to the inner-border of an organelle defined in its Selected CC attribute (A) and how a node that should be in the “cytosol” is moved from an organelle to its outer-border (B). (PNG 74.0 kb)