Additional file 1: of Alterations in the gut microbiome and metabolism with coronary artery disease severity

Figure S1. Overview of the workflow integrating CAD phenotypes, serum metabolome, gut microbiome. Figure S2. Distribution of the Gensini score in each CAD subgroup. Figure S3. Orthogonal projection to latent structure-discriminant analysis (OPLS-DA) score plots under polar ionic mode. Figure S4. Orthogonal projection to latent structure-discriminant analysis (OPLS-DA) score plots under lipid mode. Figure S5. Fine-grained correlation profile of serum metabolite clusters and physiological traits in CAD and control subjects. Figure S6. Taxonomic alpha diversity of gut microbiomes among 4 subgroups. Figure S7. Clustering of the gut microbiota based on the unweighted UniFrac distances between different groups. Figure S8. Spearman correlations between CAGs and major CAD risk factor indicators. (PDF 3080 kb)