Additional file 1: of Absence of integrin α3β1 promotes the progression of HER2-driven breast cancer in vivo

Figure S1. (a) Representative macroscopic and H&E-stained pictures of the two types of tumors detected: solid tumors with high cellularity and cystic tumors which consist of multiple large and small cysts/open areas filled with blood. Scale bar, 100 μm. (b) Quantification of solid vs cystic tumors Itga3 KO and WT mice determined by pathological analysis of excised tumors. No significant differences between both groups could be detected. (c) Immunohistochemical staining for cleaved-Cas3 marker of apoptosis in representative solid (top) and cystic (bottom) tumors of Itga3 KO and WT mice. No positive staining was observed in any of the analyzed solid tumors, and a comparable amount of apoptosis was detected in cystic tumors of Itga3 KO and WT mice. Scale bar, 100 μm. (TIF 4018 kb)