Additional file 1: of A rare functional variant of SHARPIN attenuates the inflammatory response and associates with increased risk of late-onset Alzheimer’s disease

Figure S1. Distribution of CADD scores. Figure S2. Gene expression in the brain. Figure S3. Distribution of the number of variants in genes. Figure S4. Detailed images of the immunocytochemistry shown in Fig. 2b. Figure S5. G186 of SHARPIN is highly conserved among species. Protein sequences of SHARPIN for each species were obtained from UniProt and the region near G186 was compared. Table S1. Samples used for exome sequencing. Table S2. Demographic features of the NCGG samples genotyped. Table S3. Samples used in the first association study of candidate AD risk variants. Table S4. Demographic features of the second cohort set used in the association study. Table S5. Ten genes with significantly accumulated variants. Table S6. Accumulation of variants in LOAD patients compared with NC controls. (PDF 3193 kb)