Additional file 1 of A powerful parent-of-origin effects test for qualitative traits on X chromosome in general pedigrees

Appendices and Supplementary figures. Appendix A Proof of E(S MC )=0 under the null hypothesis of no parent-of-origin effects; Appendix B Simulation study for the validity of XPPAT when testing parent-of-origin effects under X chromosome inactivation; Figs. A and B Power comparison of XPPAT full , XMCPPAT t , XMCPPAT fm , XPPAT and XPAT with N=150 and 300, respectively. The powers are calculated under four different parent-of-origin effect models with ρ=−0.05 based on 10,000 replicates at the significance level of 5%; Figs. C and D Power comparison of XPPAT full , XMCPPAT t , XMCPPAT fm , XPPAT and XPAT with N=150 and 300, respectively. The powers are calculated under four different parent-of-origin effect models with ρ=0.05 based on 10,000 replicates at the significance level of 5%. (PDF 72 kb)