Additional file 1: Figure S1. of Prognostic significance of annexin A2 and annexin A4 expression in patients with cervical cancer

Histoscore distribution of annexin A2 (ANXA2) and annexin A4 (ANXA4) expression using a quantitative image analysis. Dashed vertical lines indicate the chosen cut-off values (ANXA2 = 94 and ANXA4 = 51). Figure S2. Kaplan-Meier survival curves according to annexin A2 (ANXA2) and annexin A4 (ANXA4) mRNA expression. Data were retrieved from the GEO ( http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE44001 ) and TCGA (RNA-seq databases (version: 2015-02-24). The mRNA expression values were dichotomized according to quartile values (lower than 25 percentile vs. higher than 75 percentile). Figure S3. Correlations between annexin A2 (ANXA2) and annexin A4 (ANXA4) mRNA and protein expression. Positive correlations were noted in both ANXA2 (Spearman’s rho = 0.273, p < 0.001) and ANXA4 (Spearman’s rho = 0.293, p < 0.001). A subgroup analysis showed a positive correlation between ANXA2 expression and squamous cell carcinoma (Spearman’s rho = 0.255, p < 0.001) and ANXA4 expression and adenocarcinoma (Spearman’s rho = 0.389, p = 0.002). Figure S4. ANXA2 and ANXA4 mRNA expression according to cancer types. (Data from cBioPortal Cancer Genomics: www.cbioportal.org ). Figure S5. ANXA2 and ANXA4 mRNA expression according to HPV type infected. Data was retrieved from TCGA (RNA-seq database version 2015-02-24). (PPTX 1250 kb)