Additional file 1: Figure S1. of Directly converted patient-specific induced neurons mirror the neuropathology of FUS with disrupted nuclear localization in amyotrophic lateral sclerosis

Structures of FUS-Transportin-1 complexes. (a) Overall structure of FUS-Transportin-1 complexes are presented in blue sphere and white surface, respectively. The position of FUS (p.Q519) is marked by red sphere models. (b) The focused view around the mutation (p.Q519). The structure of FUS and Transportin-1 complexes are consisted of a ball-and-stick representation. Stick models are colored by atom (N: blue, O: red, C: gray, respectively). The important position of the mutation (p.Q519) is depicted in a red ball-and-stick representation. A possible hydrogen bonding between Q519 of FUS and E509 of Transportin-1 is shown in the red circle with the acceptor-donor distance (3.21 Å). (PDF 69 kb)