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Additional file 1: Figure S1. of Dengue virus infection-enhancement activity in neutralizing antibodies of healthy adults before dengue season as determined by using FcγR-expressing cells

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posted on 2018-01-10, 05:00 authored by Minh Ly, Meng Moi, Thi Vu, Mya Tun, Todd Saunders, Cam Nguyen, Anh Nguyen, Hung Nguyen, Than Dao, Do Pham, Thi Nguyen, Thi Le, Futoshi Hasebe, Kouichi Morita
Neutralizing antibody (N.A) profile in 34 pair serum samples obtained from 34 individuals who were DENV IgG positive pre-dengue season and demonstrated elevated DENV IgG after the season versus patient group. Neutralizing activity was determined by PRNT50 on BHK cells (A) and on FcγR-expressing BHK cells (B); Positive PRNT samples were defined as having a N.A ≥ 10 or Log2(PRNT50) ≥3.32 to any of the virus test (above dotted line). Non patient 1=pre-dengue season group; Non patient 2 = post-dengue season group; Patient = patient group. The results were represented as means of Log2 (N.A titers) ± SD. (PDF 314 kb)

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Japan Agency for Medical Research and Development (JP)

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    BMC Infectious Diseases

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    Dengue virus (DENV)Dengue virus neutralizing antibodyPrimary DENV infectionSecondary DENV infectionMonotypic, heterotypic immune response

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