Additional file 1: Figure S1. of A critical time window for the analgesic effect of central histamine in the partial sciatic ligation model of neuropathic pain

Effects of histidine administered in other regimens on mechanical allodynia (A) and thermal hyperalgesia (B) following PSL in rats. Histidine (100 mg/kg, i.p.) or saline was administered once daily during the period of 0–14 days PO, 0–7 days PO, or 8–14 days PO. *P < 0.05, **P < 0.01, and ***P < 0.001, compared with the saline-treated group. # P < 0.05, ## P < 0.01, compared with the baseline. n = 7–9/group. (TIF 1,201 kb)