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Additional file 1: Figure S1. of 6-Mercaptopurine attenuates tumor necrosis factor-α production in microglia through Nur77-mediated transrepression and PI3K/Akt/mTOR signaling-mediated translational regulation

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posted on 2016-04-13, 05:00 authored by Hsin-Yi Huang, Hui-Fen Chang, Ming-Jen Tsai, Jhih-Si Chen, Mei-Jen Wang
LPS-induced activation of PKA and MSK1 are not suppressed by 6-MP. BV-2 cells were stimulated with 100 ng/ml LPS for the indicated times with or without 16 h pretreatment with 6-MP (50 μM). Immunoblots were set up to detect phosphorylated VASP (Ser157) and MSK1 (Ser376). Images are representative of three independent experiments. (TIF 400 kb)

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