Additional file 16: Figure S11. of Development of pathogenicity predictors specific for variants that do not comply with clinical guidelines for the use of computational evidence

A hybrid predictor. A hybrid method is implicitly defined if the coincidence rule is used as a pre-classification step. In this method, the variants for which standard methods agree will be assigned this coinciding prediction; for PRDIS variants, a prediction will be obtained from the PRDIS specific method. The final performance of this hybrid method is obtained by combining that of the two cases. (PNG 607 kb)