13073_2016_276_MOESM13_ESM.pdf (2.13 MB)
Additional file 13: of Lower IgG somatic hypermutation rates during acute dengue virus infection is compatible with a germinal center-independent B cell response
journal contribution
posted on 2016-02-25, 05:00 authored by Elizabeth Godoy-Lozano, Juan Téllez-Sosa, Gilberto Sánchez-González, Hugo Sámano-Sánchez, Andrés Aguilar-Salgado, Aarón Salinas-Rodríguez, Bernardo Cortina-Ceballos, Héctor Vivanco-Cid, Karina Hernández-Flores, Jennifer Pfaff, Kristen Kahle, Benjamin Doranz, Rosa Gómez-Barreto, Humberto Valdovinos-Torres, Irma López-Martínez, Mario Rodriguez, Jesús Martínez-BarnetcheSHM rates in global and selected IGHV segments in the ImmunediveRsity -reconstructed repertoire using a CDRH3 identity clustering threshold of 92 %. Each dot represents the percentage of mutations in randomly sampled lineages per individual, classified according to clinical status. (A) Global mutation rates; (B) IGHV1-2; (C) IGHV1-18; and (D) IGHV1-69 (DWS− A, green; DWS− Pc, dark green; DWS+ A, blue; DWS+ Pc, dark blue) (Kruskal–Wallis test, Dunn’s correction for multiple testing, **p < 0.01, ***p < 0.001). (PDF 2177 kb)
