Additional file 13: of BMP-dependent, injury-induced stem cell niche as a mechanism of heterotopic ossification

Figure S10. Working model of injury-induced MSC niche. Injury-induced local microenvironment (MSC niche) is composed of niche-dwelling progenitor/stem cells (including at least Tie2-cre, Gli1-creER and Glast-creERT labeled cells) and niche supportive cells (including mast cells, neurites, vasculature and macrophages). The formation of the MSC niche likely initiates the pathological osteogenic cascade, under the co-regulation of BMP and Hh signaling through feedback and non-cell autonomous mechanisms. (TIF 1825 kb)