Additional file 12: of BMP-dependent, injury-induced stem cell niche as a mechanism of heterotopic ossification

Figure S9. Characterization of candidate niche supportive ECM molecules. A) Col4 was mainly involved in forming microtubular structures in the proposed MSC niche. B) Col6 was more ubiquitously upregulated in the proposed MSC niche. C) Interestingly, Col6 was closely associated with Tenascin C (TEN) only in early lesions. D) TEN was diffusedly upregulated in the early stages, but in the later stages, TEN was enriched mostly in mature domains. E&F) Similar to TEN, Chondroitin sulfate proteoglycan (CSPG) was also more or less evenly upregulated in early lesions but it became more defined as the proposed MSC niche formed. In contrast, laminin (LAM) was mainly involved in forming micro-tubular structures in the proposed MSC niche. A-F are on the same scale, Bar = 50 μm. (TIF 9818 kb)