13058_2015_652_MOESM12_ESM.tiff (201.41 kB)
Additional file 12: Figure S8. of The sialyl-glycolipid stage-specific embryonic antigen 4 marks a subpopulation of chemotherapy-resistant breast cancer cells with mesenchymal features
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posted on 2015-11-25, 05:00 authored by Andrea Aloia, Evgeniya Petrova, Stefan Tomiuk, Ute Bissels, Olivier DĂŠas, Massimo Saini, Franziska Zickgraf, Steve Wagner, Saskia Spaich, Marc SĂźtterlin, Andreas Schneeweiss, Manuel Reitberger, Silvia RĂźberg, Bernhard Gerstmayer, David Agorku, Sebastian KnĂśbel, Annalisa Terranegra, Monica Falleni, Laura Soldati, Martin Sprick, Andreas Trumpp, Jean-Gabriel Judde, Andreas Bosio, Stefano Cairo, Olaf HardtSSEA4-positive breast cancer cells show decreased expression of miRNAs inhibiting EMT inducers. Expression ratios of the 12 miRNAs targeting the key mesenchymal regulator and indicator genes ZEB1, ZEB2, fibronectin 1, Snail1, Snail2, and Twist. Each bar represents the log2 expression ratio of the SSEA4-positive fraction relative to the SSEA4-negative fraction for the respective tumor model. (TIFF 201 kb)
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tumor modelExpression ratiosEMT inducersSSEA 4-positive fractionSSEA 4-negative fractionTIFF 201 kbmesenchymal features SSEA 4-positive breast cancer cells showsialyl-glycolipid stage-specificlog 2 expression ratioantigen 4 marks12 miRNAsZEBmesenchymal regulatorchemotherapy-resistant breast cancer cells
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