12915_2019_674_MOESM11_ESM.tif (2.77 MB)

Additional file 11: of RNA-Seq in 296 phased trios provides a high-resolution map of genomic imprinting

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posted on 2019-06-24, 05:00 authored by Bharati Jadhav, Ramin Monajemi, Kristina Gagalova, Daniel Ho, Harmen Draisma, Mark Wiel, Lude Franke, Bastiaan Heijmans, Joyce Meurs, Rick Jansen, Peter ât Hoen, Andrew Sharp, Szymon KieĹbasa

Example of strand-specific data showing paternal expression bias at PER3/RP3-467L1.4 locus. PER3 and RP3-467L1.4 are two overlapping genes transcribed from opposite strands. PER3 shows incomplete imprinting, whereas RP3-467L1 shows stronger paternal bias in LCLs (paternal ratiosâ=â0.61 and 0.81, respectively). (TIF 2840 kb)

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Imprinting Allele-specific expression Bayesian analysis Parent-of-origin Phased genotypes

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