Additional file 10: of The potential for non-adaptive origins of evolutionary innovations in central carbon metabolism

Metabolisms viable on pyruvate as the main carbon source C can differ greatly in their viability on other carbon sources (considering only metabolisms without disconnected reactions). The figure shows a histogram of the phenotype distance (x-axis), for metabolisms without disconnected reactions with size (A) 30, (B) 35, (C) 40, and (D) 45, viable on pyruvate as carbon source C. (TIF 428 kb)