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Additional file 10: Figure S5. of Hotspot mutations delineating diverse mutational signatures and biological utilities across cancer types

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posted on 2016-06-23, 05:00 authored by Tenghui Chen, Zixing Wang, Wanding Zhou, Zechen Chong, Funda Meric-Bernstam, Gordon Mills, Ken Chen
Functional implications of hotspot mutations in RNA and protein expression. In OV, tumor samples with missense hotspot mutations (I195, Y220, R248 and R273) in TP53 show higher TP53 RNA and protein expression than those with non-hotspot mutations and without TP53 mutations. * indicates p < 0.05 and ** indicates p < 0.001 between samples with specified hotspot mutations and samples with non-hotspot mutations in examined gene; # indicates p < 0.05 and ## indicates p < 0.001 between samples with specified hotspot mutations and samples without mutations in examined gene. (PDF 365 kb)

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