Additional file1: of Associations of sex hormone-binding globulin and testosterone with genome-wide DNA methylation

Supplementary Methods of ALSPAC data description and Results Table S1. SHBG, total testosterone and bioavailable testosterone measures available in ALSPAC. Values presented for all ALSPAC participants regardless of DNA methylation data availability. Figure S1. Distributions of SHBG in males at 9.9, 17.8 years and in females at 15.5 years. Graphs include only individuals with available DNA methylation data in ARIES. Figure S2. Distributions of total testosterone in males at 9.9 and 17.8 years and in females at 15.5 years. Graphs include only individuals with available DNA methylation data in ARIES. Figure S3. Distributions of bioavailable testosterone in males at 9.9 and 17.8 years. Graphs include only individuals with available DNA methylation data in ARIES. Figure S4. QQ plots of SHBG EWAS at 9.9 and 17.8 years in males and 15.5 years in females. Figure S5. QQ plots of total testosterone EWAS at 9.9 and 17.8 years in males and 15.5 years in females. Figure S6. QQ plots of total testosterone EWAS at 9.9 and 17.8 years in males. Figure S7. QQ-plots of EWAS models of rs12150660 in childhood and adolescence, stratified by sex. (DOCX 472 kb)