MOESM12 of STAT3 induces G9a to exacerbate HER3 expression for the survival of epidermal growth factor receptor-tyrosine kinase inhibitors in lung cancers Yi-Fang Chang Ken-Hong Lim Ya-Wen Chiang Zong-Lin Sie Jungshan Chang Ai-Sheng Ho Chun-Chia Cheng 10.6084/m9.figshare.9993545.v1 https://springernature.figshare.com/articles/figure/MOESM12_of_STAT3_induces_G9a_to_exacerbate_HER3_expression_for_the_survival_of_epidermal_growth_factor_receptor-tyrosine_kinase_inhibitors_in_lung_cancers/9993545 Additional file 12: Figure S4. BBI608 and UNC0642 led to apoptosis in A549 cells. Apoptosis was detected in BBI608- and UNC0642-treated A549 cells using a flow cytometry, whereas FL1-H and FL2-H represented annexin-FITC and propidium iodide staining, respectively. Results indicate that BBI608 and UNC0642 caused A549 apoptosis from 1.06 to 45.08% by 1 μg/mL concentration and from 0.17 to 11.85% by 10 μg/mL concentration, respectively, for 4 h incubation. (TIF 396 kb) 2019-10-17 04:58:58 BBI608 EGFR G9a HER3 Lung cancer STAT3