%0 Journal Article %A Ghosh, Abhinaba %A Torraville, Sarah %A Mukherjee, Bandhan %A Walling, Susan %A Martin, Gerard %A Harley, Carolyn %A Yuan, Qi %D 2019 %T Additional file 6: of An experimental model of Braak’s pretangle proposal for the origin of Alzheimer’s disease: the role of locus coeruleus in early symptom development %U https://springernature.figshare.com/articles/journal_contribution/Additional_file_6_of_An_experimental_model_of_Braak_s_pretangle_proposal_for_the_origin_of_Alzheimer_s_disease_the_role_of_locus_coeruleus_in_early_symptom_development/8479922 %R 10.6084/m9.figshare.8479922.v1 %2 https://springernature.figshare.com/ndownloader/files/15743837 %K Locus coeruleus %K Norepinephrine %K Hyperphosphorylated tau %K Pretangles %K Odor discrimination %K Odor identification deficit %X Neurons and microglia, but not astrocytes, show uptake of htauE14. a1–a3. An example of GFAP labeling in the old rat brain as in Fig. 6. b1–b3. A GFP and Iba-1 double-labeled cell. c1–c3. An example of an Iba-1 stained microglia in a young htauE14 rat in the same region as in b. Note retracted morphology of Iba-1 cell in b compared to c. d1–d3. A GFP and NeuN double-labeled cell in the old rat brain. Scale bars, 25 μm. (PDF 2568 kb) %I figshare